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Thoro-Graph
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While it is true that the ointment contains the valerate form of betamethasone and the injectable form commonly used for joint treatment is composed of the acetate form, it would not be difficult at all to hide the intra-articular use of betamethasone by formulating betamethasone valerate in an injectable medium, while simultaneously treating the skin condition with the legal medication that also
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Electrocutionist
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Glad to see you guys bury the hatchet. Ok, I could have said "kiss and make up" but chose not to. I don't post much unless I think it's important. I've read both your comments over the years and always appreciated your points of view.
My only beef with the SNL bit is that it repeats the commonly held belief that all steroids are bad and all are performance enhancers.
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Electrocutionist
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I agree, his story made no sense and it took him a while to land on an explanation that made scientific sense (Otomax). My own speculation is that it was more likely to have been caused by a joint injection administered too close to race day, and clearance could have been inhibited by the Otomax. But that is speculation, I have no facts in that regard. Regardless, if the standard is to disqualify
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Electrocutionist
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Guys-
Thanks for your responses. I'm just trying to see myself if that Derby beat was legit. But looking at the combination of drugs in Otomax, one drug affects the metabolism of the other, and it is highly unlikely that that has ever been considered properly by the regulatory folks. I agree though that Baffert's flailing for a legitimate-sounding excuse doesn't help his case. Uri
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Looking into this further, I see that Otomax also contains the antifungal agent clotrimazole. Clotrimazole is a well-known inhibitor of a liver enzyme called CYP3A4, which is the primary liver enzyme involved in detoxification (breakdown and subsequent elimination of drugs). CYP3A4 is the primary enzyme involved in betamethasone degradation. Thus, the presence of clotrimazole in the Otomax could
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Electrocutionist
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As a horseracing fan and scientist who has spent a career studying steroid metabolism in farm animals, I’d like to share my thoughts on the current discussion. Full disclosure, I do have a dog in this fight since in addition to a win bet on Mandaloun I had boxed the exacta of Mandaloun, Hot Rod Charlie and Essential Quality in the third futures pool back in February. The Mandaloun-Hot Rod Charl
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Electrocutionist
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